A myoglobin evolved from indoleamine 2, 3-dioxygenase

IDO 2 ( indoleamine 2 , 3 - dioxygenase 2 )

the immunoregulatory function of indoleamine 2, 3 dioxygenase and its application in allotransplantation

indolemine 2, 3-dioxygenase (ido) is a cytosolic monomeric hemoprotein enzyme that catalyses tryptophan, the least available essential amino acid in the human body, to n-formylkynurenine, which in turn rapidly degrades to give kynurenine. ido is expressed in different tissues, especially and prominently in some subsets of antigen presenting cells (apcs) of lymphoid organs and also in the placen...

Chemical Components from Aloe and their Inhibition of Indoleamine 2, 3-dioxygenase

BACKGROUND In Korea, Aloe is routinely ingested as a traditional medicine or as a component of health beverages. OBJECTIVE To research the inhibition of indoleamine 2, 3-dioxygenase (IDO) activities of components from Aloe. MATERIALS AND METHODS the compounds were isolated by a combination of silica gel and YMC Rp-18 column chromatography, and their structures were identified by analysis of...

Plasma Indoleamine 2, 3-Dioxygenase, a Biomarker for Tuberculosis in Human Immunodeficiency Virus-Infected Patients

Background There is no biomarker for diagnosing active tuberculosis in patients with human immunodeficiency virus (HIV) infection. Indoleamine 2, 3-dioxygenase (IDO) is an immunoregulatory enzyme that breaks down tryptophan (Trp) to metabolites known as kynurenines (Kyns). We investigated whether IDO activity, as measured by the ratio of Kyn to Trp, could be used to diagnose or predict active t...

the 14kda protein molecule isolated from garlic suppresses indoleamine 2, 3-dioxygenase metabolites in mononuclear cells in vitro

a wide range of biological activities of garlic in vitro and in vivo have been verified including its antioxidant, antitumor and anti-inflammatory effects. indoleamine 2,3-dioxygenase (ido) is an enzyme widely distributed in mammals and is inducible preferentially by ifn-γ. ido degrades the essential amino acid tryptophan to form n-formyl kynurenine. in the present in vitro study, the modulator...